AI Article Synopsis
- Umbilical cord blood (UCB) is a promising source for hematopoietic stem/progenitor cell (HSPC) transplantation, but effective large-scale preparation methods are lacking.
- Researchers have identified a peptide called CH02 that enhances the proliferation of CD34 UCB-HSPCs by activating FLT3 signaling, leading to a significant 12-fold increase in cell expansion.
- CH02-preconditioned UCB-HSPCs have shown improved effectiveness in promoting wound healing in diabetic mice, highlighting the potential clinical applications of this strategy for large-scale HSPC preparation.
Article Abstract
Umbilical cord blood (UCB) is an advantageous source for hematopoietic stem/progenitor cell (HSPC) transplantation, yet the current strategies for large-scale and cost-effective UCB-HSPC preparation are still unavailable. To overcome these obstacles, we systematically evaluate the feasibility of our newly identified CH02 peptide for expansion of CD34 UCB-HSPCs. We herein report that the CH02 peptide is specifically enriched in HSPC proliferation via activating the FLT3 signaling. Notably, the CH02-based cocktails are adequate for boosting 12-fold expansion of UCB-HSPCs. Meanwhile, CH02-preconditioned UCB-HSPCs manifest preferable efficacy upon wound healing in diabetic mice via bidirectional orchestration of proinflammatory and anti-inflammatory factors. Together, our data indicate the advantages of the CH02-based strategy for expansion of CD34 UCB-HSPCs, which will provide new strategies for further development of large-scale HSPC preparation for clinical purposes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577473 | PMC |
| http://dx.doi.org/10.3724/abbs.2023047 | DOI Listing |
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