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Causal effects of genetically determined circulating metabolites on endometriosis: A Mendelian randomization study.
Medicine (Baltimore)
November 2024
Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Endometriosis (EMs) is a common gynecological disease accompanied by metabolic disturbances. However, the causality between metabolites and the risk of EMs remains unclear. We conducted a 2-sample Mendelian randomization (MR) analysis using the publicly available genome-wide association study (GWAS) of 486 circulating metabolites and EMs.
View Article and Find Full Text PDFGenetically Confirmed Optimal Causal Association of Cerebrospinal Fluid Metabolites With Hemorrhagic Stroke.
J Neurochem
January 2025
NHC Key Laboratory of Cell Transplantation, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hemorrhagic stroke (HS) mainly includes intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), both of which seriously affect the patient's prognosis. Cerebrospinal fluid (CSF) metabolites and HS showed a link in observational studies. However, the causal association between them is not clear.
View Article and Find Full Text PDFBletilla striata polysaccharide-mediated trained immunity drives the hematopoietic progenitors' expansion and myelopoiesis.
Int Immunopharmacol
January 2025
Jiangxi Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Vascular Remodeling Diseases, Jiangxi University of Chinese Medicine, Nanchang 330006, China; National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herb Medicine, Jiangxi University of Chinese Medicine, Nanchang 330006, China; Department of Cardiovascular Sciences and Centre for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address:
Trained immunity represents a functional state of the innate immune response, characterized by enduring epigenetic reprogramming of innate immune cells. This phenomenon facilitates a sustained and advantageous reaction of myeloid cells to subsequent challenges. Bletilla striata polysaccharide (BSP) is the primary active component of Bletilla striata, mainly consisting of mannose and glucose in its chemical structure.
View Article and Find Full Text PDFEffects of polysaccharide fractions isolated from the pulp of rose laevigata Michx fruit on the foaming and polarization of RAW264.7 macrophage cells.
Int J Biol Macromol
December 2024
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address:
The foaming and polarization of macrophages are pivotal in the formation and development of atherosclerosis. This study delved into the structure and membrane pattern recognition receptors (PRRs) of the neutral polysaccharide fraction (PPRLMF-1), investigating effects of PPRLMF-1 and acid polysaccharide fraction (PPRLMF-2) on the foaming and polarization of RAW264.7 macrophage cells, and exploring their underlying mechanisms.
View Article and Find Full Text PDFAntibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference.
bioRxiv
December 2024
Department of Biochemistry, University of Washington, Seattle, WA.
A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, the most studied lectin adhesin of type 1 fimbriae in , undergoes an allosteric transition from an inactive to an active conformation that can act as a catch-bond. Monoclonal antibodies that alter FimH glycan binding in various ways are available, but the mechanisms of these antibodies remain unclear.
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