AI Article Synopsis
- High-resolution omics techniques, especially single-cell and spatial transcriptomics, are improving our understanding of gliovascular cell diversity and age-related changes that lead to neurodegeneration.
- The review emphasizes new molecular features of neurovascular and glial cells identified through omic profiling, focusing on those with functional significance and differences between humans and mice, particularly related to aging and inflammation in neurodegenerative diseases.
- It also discusses how omic profiling can aid in discovering biomarkers and developing therapies to modify disease progression in neurodegenerative conditions.
Article Abstract
High-resolution omics, particularly single-cell and spatial transcriptomic profiling, are rapidly enhancing our comprehension of the normal molecular diversity of gliovascular cells, as well as their age-related changes that contribute to neurodegeneration. With more omic profiling studies being conducted, it is becoming increasingly essential to synthesise valuable information from the rapidly accumulating findings. In this review, we present an overview of the molecular features of neurovascular and glial cells that have been recently discovered through omic profiling, with a focus on those that have potentially significant functional implications and/or show cross-species differences between human and mouse, and that are linked to vascular deficits and inflammatory pathways in ageing and neurodegenerative disorders. Additionally, we highlight the translational applications of omic profiling, and discuss omic-based strategies to accelerate biomarker discovery and facilitate disease course-modifying therapeutics development for neurodegenerative conditions.
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| http://dx.doi.org/10.1016/j.semcdb.2023.06.005 | DOI Listing |
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