Putting transcriptional brakes on fibrosis: a negative regulator of TGFβ signaling.

Trends Cell Biol

Renal Division Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Published: September 2023

Due to the pleiotropic effect of transforming growth factor β (TGFβ) signaling inhibition, function-specific targeted inhibition of TGFβ signaling is required. In a recent study, Yang et al. found that Krüppel-like factor (KLF)-13 acts as a negative regulator of TGFβ. Thus, activating KLF13 in fibrotic tissues may protect them from fibrosis by decreasing TGFβ signaling.

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http://dx.doi.org/10.1016/j.tcb.2023.06.003DOI Listing

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