AI Article Synopsis
- The epigenetic landscape is crucial for maintaining cellular balance, and disruption to this balance can result in cancer.
- Noncoding RNAs (ncRNAs) play a key role in regulating epigenetic processes like histone modification and DNA methylation, affecting various cancer pathways.
- Understanding how ncRNA networks influence epigenetic changes is vital for developing targeted cancer treatments that can modify cellular epigenetics.
Article Abstract
The epigenetic landscape has an important role in cellular homeostasis and its deregulation leads to cancer. Noncoding (nc)RNA networks function as major regulators of cellular epigenetic hallmarks via regulation of vital processes, such as histone modification and DNA methylation. They are integral intracellular components affecting multiple oncogenic pathways. Thus, it is important to elucidate the effects of ncRNA networks on epigenetic programming that lead to the initiation and progression of cancer. In this review, we summarize the effects of epigenetic modification influenced by ncRNA networks and crosstalk between diverse classes of ncRNA, which could aid the development of patient-specific cancer therapeutics targeting ncRNAs, thereby altering cellular epigenetics.
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| http://dx.doi.org/10.1016/j.drudis.2023.103690 | DOI Listing |
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