AI Article Synopsis

  • Breast cancer is the most commonly diagnosed cancer in women, and geraniol, a phytochemical, shows strong anti-tumoral potential but its mechanism in breast cancer is not fully understood.* -
  • This study investigates the therapeutic and chemosensitizing effects of geraniol on breast carcinoma in mice, focusing on tumor biomarkers and histopathology.* -
  • Results indicated that geraniol significantly reduces tumor growth, promotes apoptosis, and enhances the effectiveness of the chemotherapy drug 5-fluorouracil, suggesting it could be a valuable treatment option for breast cancer.*

Article Abstract

Objectives: Breast cancer is the most diagnosed cancer in females worldwide. Phytochemicals are among the recent compelling approaches showing anticancer activity. Geraniol is a monoterpenoid showing anti-tumoral potential in cell lines. However, its exact mechanism in breast cancer has not been elucidated. In addition, the possible chemosenstizing effect of geraniol when combined with chemotherapeutic drugs in breast carcinoma has not been previously addressed.

Methods: Therefore, the aim of the current work is to investigate the potential therapeutic as well as chemosensitizing effects of geraniol on breast carcinoma induced in mice through examination of tumour biomarkers and histopathology profile.

Key Findings: Results showed a prominent suppression of tumour growth following geraniol treatment. This was accompanied with miR-21 downregulation that subsequently upregulated PTEN and suppressed mTOR levels. Geraniol was also able to activate apoptosis and inhibit autophagy. Histopathological examination revealed high necrosis areas separating malignant cells in the geraniol-treated group. Combined geraniol and 5-fluorouracil treatment induced more than 82% inhibition of tumour rate, surpassing the effect of each drug alone.

Conclusions: It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs.

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Source
http://dx.doi.org/10.1093/jpp/rgad060DOI Listing

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