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Peptide-based metalloporphyrin catalysts: unveiling the role of the metal ion in indole oxidation. | LitMetric

Peptide-based metalloporphyrin catalysts: unveiling the role of the metal ion in indole oxidation.

J Inorg Biochem

Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, via Cintia, 80126 Naples, Italy. Electronic address:

Published: September 2023

AI Article Synopsis

Article Abstract

Over the last decades, much effort has been devoted to the construction of protein and peptide-based metalloporphyrin catalysts capable of promoting difficult transformations with high selectivity. In this context, mechanistic studies are fundamental to elucidate all the factors that contribute to catalytic performances and product selectivity. In our previous work, we selected the synthetic peptide-porphyrin conjugate MnMC6*a as a proficient catalyst for indole oxidation, promoting the formation of a 3-oxindole derivative with unprecedented selectivity. In this work, we have evaluated the role of the metal ion in affecting reaction outcome, by replacing manganese with iron in the MC6*a scaffold. Even though product selectivity is not altered upon metal substitution, FeMC6*a shows a lower substrate conversion and prolonged reaction times with respect to its manganese analogue. Experimental and theoretical studies have enabled us to delineate the reaction free energy profiles for both catalysts, indicating different thermodynamic limiting steps, depending on the nature of the metal ion.

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Source
http://dx.doi.org/10.1016/j.jinorgbio.2023.112298DOI Listing

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