Minichromosome Maintenance 8 Homologous Recombination Repair Factor (MCM8) and Minichromosome Maintenance 9 Homologous Recombination Repair Factor (MCM9) are recently discovered minichromosome maintenance proteins and are implicated in multiple DNA-related processes and pathologies, including DNA replication (initiation), meiosis, homologous recombination and mismatch repair. Consistent with these molecular functions, variants of may predispose carriers to disorders such as infertility and cancer and should therefore be included in relevant diagnostic testing. In this overview of the (patho)physiological functions of MCM8 and MCM9 and the phenotype of variant carriers, we explore the potential clinical implications of variant carriership and highlight important future directions of MCM8 and MCM9 research. With this review, we hope to contribute to better variant carrier management and the potential utilization of MCM8 and MCM9 in other facets of scientific research and medical care.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291252PMC
http://dx.doi.org/10.1016/j.isci.2023.106737DOI Listing

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