AI Article Synopsis
- Pancreatic stellate cells (PSCs) are important in developing fibrosis in the pancreas and its islets, but their exact role was not fully understood before this study.
- Researchers used a new technique involving vitamin A in genetically modified mice to trace the fate of PSCs, discovering that these cells contribute significantly (about 65.7%) to myofibroblast formation in pancreatic fibrosis.
- The study found that while PSCs play a crucial role in pancreatic exocrine fibrosis, their genetic removal improved this condition but not islet fibrosis, highlighting their complex involvement in fibrogenesis in the pancreas.
Article Abstract
Pancreatic stellate cells (PSCs) are suggested to play an important role in the development of pancreas and islet fibrosis. However, the precise contributions and solid evidence of PSCs to the fibrogenesis remain to be elucidated. Here, we developed a novel fate-tracing strategy for PSCs by vitamin A administration in Lrat-cre; Rosa26-tdTomato transgenic mouse. The results showed that stellate cells give rise to 65.7% of myofibroblasts in cerulein-induced pancreatic exocrine fibrosis. In addition, stellate cells in islets increase and contribute partly to myofibroblasts pool in streptozocin-induced acute or chronic islet injury and fibrosis. Furthermore, we substantiated the functional contribution of PSCs to fibrogenesis of pancreatic exocrine and islet in PSCs ablated mice. We also found stellate cells' genetic ablation can improve pancreatic exocrine but not islet fibrosis. Together, our data indicates that stellate cells are vital/partial contributors to myofibroblasts in pancreatic exocrine/islet fibrosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291507 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.106988 | DOI Listing |
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