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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290946 | PMC |
| http://dx.doi.org/10.1016/j.cjco.2022.12.009 | DOI Listing |
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Diazoxide-Associated Hyperglycemia: A Critical Case Precipitating Hyperosmolar Hyperglycemic State in a Child.
J Med Toxicol
January 2025
Division of Pediatric Emergency Medicine, Johns Hopkins Children's Center, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Introduction: Diazoxide is the first-line treatment for children with hyperinsulinemic hypoglycemia (HI). In these cases, diazoxide raises blood glucose levels by suppressing insulin release, preventing hypoglycemia, and potentially devastating end-organ sequelae. Hyperosmolar hyperglycemic state (HHS) is an exceedingly rare side effect of diazoxide.
View Article and Find Full Text PDFRetrospective Comparison of Early Versus Late Initiation of Long-Acting Insulin in Critically Ill Pediatric Patients in Diabetic Ketoacidosis.
J Pediatr Pharmacol Ther
December 2024
Department of Pharmacy, Stormont Vail Health, Topeka, KS.
Objective: Determine whether early administration (EA) of long-acting insulin in pediatric diabetic -ketoacidosis (DKA) reduces time to acidosis resolution while maintaining safety when compared with late administration (LA).
Methods: This retrospective review compared EA (within 4 hours) to LA (4 to 24 hours) of long-acting insulin in DKA management in the pediatric intensive care unit between 2015 and 2022. Admissions were excluded for patients ≥18 years of age, without type 1 diabetes, with insufficient laboratory data, or who did not receive insulin glargine within 24 hours of starting treatment.
Diazoxide toxicity in congenital hyperinsulinism: A case report.
World J Clin Pediatr
December 2024
Department of Pediatrics, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Institute, Milan 20132, Lombardy, Italy.
Background: Diazoxide is the sole approved drug for congenital hyperinsulinism; however, diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse effects. This report aims to highlight a seldom-considered rare side effect of diazoxide. We believe that this brief report is of general interest to readership and increase the physicians' awareness of the guideline importance.
View Article and Find Full Text PDFRobotic-assisted pancreatic enucleation: Posterior uncinate approach.
Updates Surg
December 2024
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Article Synopsis
- - Functional pancreatic neuroendocrine tumors (pNET) require surgical removal, with enucleation being the top choice for small, well-differentiated tumors under 2 cm.
- - Insulinomas, a type of pNET, are ideal candidates for enucleation, but surgeries involving the uncinate process of the pancreas can be complex.
- - A video demonstrates a successful robotic-assisted enucleation of an insulinoma in a 41-year-old man, resulting in symptom relief and low post-operative complications.
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