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stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment. | LitMetric
The individual motifs that respond to specific stimuli for the self-assembly of nanomaterials play important roles. constructed nanomaterials are formed spontaneously without human intervention and have promising applications in bioscience. However, due to the complex physiological environment of the human body, designing stimulus-responsive self-assembled nanomaterials is a challenging problem for researchers. In this article, we discuss the self-assembly principles of various nanomaterials in response to the tissue microenvironment, cell membrane, and intracellular stimuli. We propose the applications and advantages of self-assembly in drug delivery and disease diagnosis and treatment, with a focus on self-assembly at the lesion site, especially in cancer. Additionally, we introduce the significance of introducing exogenous stimulation to construct self-assembly . Based on this foundation, we put forward the prospects and possible challenges in the field of self-assembly. This review uncovers the relationship between the structure and properties of self-assembled nanomaterials and provides new ideas for innovative drug molecular design and development to solve the problems in the targeted delivery and precision medicine.
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