AI Article Synopsis
- Dengue virus (DENV) has been a persistent public health issue in Paraguay since 1988, despite ongoing control measures.
- Researchers conducted genomic surveillance and analyzed DENV strains to identify multiple serotypes circulating in the country, including DENV-1, DENV-2, and DENV-4.
- Findings indicated Brazil as a potential source of DENV strain spread, highlighting the importance of enhanced cross-border surveillance for effective outbreak prevention and response.
Article Abstract
Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304136 | PMC |
| http://dx.doi.org/10.3390/v15061275 | DOI Listing |
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