AI Article Synopsis
- Avian infectious bronchitis is a contagious disease caused by the infectious bronchitis virus (IBV), with a study identifying 15 novel strains from chicken samples in southern China between 2021 and 2022.
- Phylogenetic analysis showed that these strains primarily belong to the QX type, closely related to the prevalent LX4 type, and involved frequent recombination events, particularly in specific genetic lineages.
- Research indicates that current vaccines are ineffective against these emerging IBV strains, highlighting a concerning trend in disease prevalence and the potential for ongoing outbreaks in the region.
Article Abstract
Avian infectious bronchitis is a serious and highly contagious disease that is caused by the infectious bronchitis virus (IBV). From January 2021 to June 2022, 1008 chicken tissue samples were collected from various regions of southern China, and 15 strains of the IBV were isolated. Phylogenetic analysis revealed that the strains mainly comprised the QX type, belonging to the same genotype as the currently prevalent LX4 type, and identified four recombination events in the S1 gene, among which lineages GI-13 and GI-19 were most frequently involved in recombination. Further study of seven selected isolates revealed that they caused respiratory symptoms, including coughing, sneezing, nasal discharge, and tracheal sounds, accompanied by depression. Inoculation of chicken embryos with the seven isolates resulted in symptoms such as curling, weakness, and bleeding. Immunization of specific pathogen-free (SPF) chickens with inactivated isolates produced high antibody levels that neutralized the corresponding strains; however, antibodies produced by vaccine strains were not effective in neutralizing the isolates. No unambiguous association was found between IBV genotypes and serotypes. In summary, a new trend in IBV prevalence has emerged in southern China, and currently available vaccines do not provide protection against the prevalent IBV strains in this region, facilitating the continued spread of IBV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301595 | PMC |
| http://dx.doi.org/10.3390/v15061273 | DOI Listing |
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