AI Article Synopsis
- Glucose oxidase (GOD) catalyzes the oxidation of glucose into hydrogen peroxide and gluconic acid, but has limitations like instability and complex purification, affecting its biomedical uses.
- Recent advancements in artificial nanomaterials with GOD-like activity show promise for better catalytic efficiency, making them suitable for biosensing and treatment of diseases.
- The review highlights notable GOD-mimicking nanomaterials, their catalytic mechanisms, strategies to enhance their effectiveness, and potential applications in glucose detection, DNA analysis, and cancer treatment.
Article Abstract
Glucose oxidase (GOD) is an oxidoreductase that catalyzes the aerobic oxidation of glucose into hydrogen peroxide (HO) and gluconic acid, which has been widely used in industrial raw materials production, biosensors and cancer treatment. However, natural GOD bears intrinsic disadvantages, such as poor stability and a complex purification process, which undoubtedly restricts its biomedical applications. Fortunately, several artificial nanomaterials have been recently discovered with a GOD-like activity and their catalytic efficiency toward glucose oxidation can be finely optimized for diverse biomedical applications in biosensing and disease treatments. In view of the notable progress of GOD-mimicking nanozymes, this review systematically summarizes the representative GOD-mimicking nanomaterials for the first time and depicts their proposed catalytic mechanisms. We then introduce the efficient modulation strategy to improve the catalytic activity of existing GOD-mimicking nanomaterials. Finally, the potential biomedical applications in glucose detection, DNA bioanalysis and cancer treatment are highlighted. We believe that the development of nanomaterials with a GOD-like activity will expand the application range of GOD-based systems and lead to new opportunities of GOD-mimicking nanomaterials for various biomedical applications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301434 | PMC |
| http://dx.doi.org/10.3390/molecules28124615 | DOI Listing |
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