Six compounds including three new benzophenones, selagibenzophenones D-F (-), two known selaginellins (-) and one known flavonoid (), were isolated from . The structures of new compounds were established by 1D-, 2D-NMR and HR-ESI-MS spectral analyses. Compound represents the second example of diarylbenzophenone from natural sources. Compound possesses an unusual biphenyl-bisbenzophenone structure. Their cytotoxicity against human hepatocellular carcinoma HepG2 and SMCC-7721 cells and inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compound showed moderate inhibitory activity against HepG2 and SMCC-7721 cells, and compounds and showed moderate inhibitory activity to HepG2 cells. Compounds and also exhibited inhibitory activities on lipopolysaccharide-induced nitric oxide (NO) production.
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| http://dx.doi.org/10.3390/molecules28124582 | DOI Listing |
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