AI Article Synopsis
- Sarcopenia, a condition characterized by muscle loss, affects 15.7% of patients with non-alcoholic fatty liver disease (NAFLD), all of whom were female and had a median age of 56.
- Patients with sarcopenia also displayed a poorer metabolic profile and significantly lower quality of life, particularly in physical health, compared to those without sarcopenia.
- Depression and clinically significant fatigue were found to be independent risk factors for developing sarcopenia in NAFLD patients, indicating a complex relationship beyond liver disease severity alone.
Article Abstract
Background: Sarcopenia is thought to be related to an increased risk of non-alcoholic steatohepatitis and advanced liver fibrosis. Our cross-sectional single-center study was designed to analyze the prevalence of sarcopenia in patients with NAFLD and possible influencing factors.
Methods: A survey on the presence of sarcopenia, fatigue, anxiety, and depression, along with a quality-of-life (QoL) assessment, was forwarded by email to 189 outpatients. Demographics, anthropometric and clinical data (laboratory test results and abdomen complete ultrasound protocol), performed within 2-4 weeks prior to the enrollment, were obtained.
Results: Sarcopenia (defined as SARC-F score ≥ 4) was identified in 17 (15.7%) patients, all of them (100%) females, with median age (interquartile range) 56 (51-64) years. These patients had a poorer metabolic state (greater values of waist and hip circumferences, body mass index, and HOMA-IR) and significantly poorer QoL, specifically, regarding the physical component of health, compared with NAFLD patients without sarcopenia. Multivariate analysis showed that depression (OR = 1.25, 95% CI: 1.02-1.53, = 0.035) and clinically meaningful fatigue (OR = 1.14, 95% CI: 1.04-1.26, = 0.008) were the factors independently associated with sarcopenia in patients with NAFLD.
Conclusion: Sarcopenia is associated with depression and fatigue rather than with the severity of liver disease alone and may negatively affect QoL in patients with NAFLD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302668 | PMC |
| http://dx.doi.org/10.3390/jpm13060932 | DOI Listing |
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