Thank you for allowing us the opportunity to respond to the commentary from Mistry and colleagues (Comment: The two substrate reduction therapies for type 1 Gaucher disease are not equivalent) [...].
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http://dx.doi.org/10.3390/jcm12124017 | DOI Listing |
Light-driven biotransformations in recombinant cyanobacteria benefit from the atom-efficient regeneration of reaction equivalents like NADPH from water and light by oxygenic photosynthesis. The self-shading of photosynthetic cells throughout the reaction volume, along with the need for extended light paths, limits adequate light supply and significantly restricts the potential for upscaling. Here, we present a flat panel photobioreactor (1 cm optical path length) as a scalable system to provide efficient illumination at high cell densities.
View Article and Find Full Text PDFFood Res Int
February 2025
Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark. Electronic address:
Xanthine oxidase (XO) and lactoperoxidase (LPO) are highly abundant enzymes in milk. Their substrates, xanthine and thiocyanate, are found in elevated amounts in infant saliva, leading to a proposed interaction between milk and saliva referred to as the XO-LPO system. This system is suggested to generate reactive oxygen and nitrogen species with potential antibacterial effects.
View Article and Find Full Text PDFNat Chem
January 2025
TUM School of Natural Sciences, Department of Chemistry, Chair of Inorganic and Metal-Organic Chemistry and Catalysis Research Center, Technical University of Munich, Garching, Germany.
The exploration of ligated metal clusters' chemical space is challenging, partly owing to an insufficiently targeted access to reactive clusters. Now, dynamic mixtures of clusters, defined as living libraries, are obtained through organometallic precursor chemistry. The libraries are populated with interrelated clusters, including transient and highly reactive ones, as well as more accessible but less reactive species.
View Article and Find Full Text PDFJ Endod
January 2025
School of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia. Electronic address:
Introduction: This in vitro study assessed how shade changes induced by endodontic medicaments affect the transmission of single and multiples wavelengths of infrared light through enamel and dentin.
Methods: Eighteen extracted single-rooted permanent teeth were prepared, removing all extrinsic staining, and cementum. Tooth slices were treated for 4 weeks with UltraCal™ XS, Ledermix™, or were untreated controls.
Microb Pathog
January 2025
Postgraduate Program in Biological Sciences (PPGCB), Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil. Electronic address:
The NorA and TetK efflux pumps mediate resistance to fluoroquinolone and tetracycline antibiotics by actively extruding these compounds and reducing their intracellular concentrations. Consequently, intense research has focused on inhibiting these efflux mechanisms using antimicrobial agents derived from natural or synthetic sources. This study used Fourier transform infrared spectroscopy (ATR-FTIR) to analyze the various functional groups present in p-coumaric acid.
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