Estimating time since death can be challenging for forensic experts, and is one of the most challenging activities concerning the forensic world. Various methods have been assessed to calculate the postmortem interval on dead bodies in different stages of decomposition and are currently widely used. Nowadays, the only well-recognized dating technique is carbon-14 radioisotope measurement, whereas other methods have been tested throughout the years involving different disciplines with different and sometimes not univocal results. Today, there is no precise and secure method to precisely determine time since death, and late postmortem interval estimation remains one of the most debated topics in forensic pathology. Many proposed methods have shown promising results, and it is desirable that with further studies some of them might become acknowledged techniques to resolve such a difficult and important challenge. The present review aims at presenting studies about the different techniques that have been tested in order to find a valuable method for estimating time since death for skeletal remains. By providing a comprehensive overview, the purpose of this work is to offer readers new perspectives on postmortem interval estimation and to improve current practice in the management of skeletal remains and decomposed bodies.
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http://dx.doi.org/10.3390/biology12060783 | DOI Listing |
Ann Neurol
January 2025
Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Objective: Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post-mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive-diagnosed with idiopathic PD have an alternative post-mortem diagnosis. We evaluated the diagnostic accuracy of PD comparing the in-vivo clinical diagnosis with the post-mortem diagnosis performed through the pathological examination in 2 groups.
View Article and Find Full Text PDFBiomedicines
January 2025
Faculty of Law and Criminology, Maastricht University, Minderbroedersberg 4-6, 6211 LK Maastricht, The Netherlands.
The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical stimulation for estimating the post-mortem interval in daily forensic practice. Knowledge concerning the post-mortem cell mechanisms accounting for the post-mortem excitability of skeletal muscle is lacking.
View Article and Find Full Text PDFBiomedicines
January 2025
Institute of Legal Medicine, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
Background/objectives: Differential diagnosis of sudden cardiac death (SCD) remains challenging, particularly in cases lacking evident structural abnormalities. Cardiac markers have been proposed as useful tools for this differentiation in forensic contexts. However, key issues include the influence of postmortem interval (PMI) on marker stability and the limitations of traditional approaches that focus on pericardial fluid, which requires invasive sampling compared to peripheral blood.
View Article and Find Full Text PDFSci Justice
January 2025
Department of Forensic Medicine, Soochow University, Ganjiang East Road, Suzhou, China. Electronic address:
The age of the oldest immature insects present on a cadaver is typically used by forensic entomologists to estimate the minimum postmortem interval (PMI). The green bottle fly, Lucilia sericata (Meigen, 1826), known for its widespread distribution and necrophagy, is of considerable significance in forensic science. This study aimed to investigate potential regional developmental disparities between populations of L.
View Article and Find Full Text PDFSci Justice
January 2025
Laboratory of Criminalistics, Adam Mickiewicz University in Poznań, al. Niepodległości 53, Poznań 61-714, Poland; Centre for Advanced Technologies, Adam Mickiewicz University in Poznań, ul. Uniwersytetu Poznańskiego 10, Poznań 61-614, Poland.
While estimating postmortem interval (PMI) ambient temperature plays a pivotal role, so its reconstruction is crucial for forensic scientists. The recommended procedure is to correct temperatures from the nearest meteorological station based on measurements from the death scene; typically applying linear regression. Recently, there have been attempts to use different algorithms, that can improve that correction, for example GAM algorithm.
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