AI Article Synopsis
- The study examines how eugenol (EUG) affects cigarette smoke (CS)-induced acute lung injury (ALI) and its impact on macrophage function.
- EUG was administered to mice exposed to cigarette smoke for five days, showing a decrease in inflammation and oxidative stress.
- In laboratory tests, EUG balanced oxidative stress in rat macrophages by lowering pro-inflammatory cytokines and increasing anti-inflammatory ones, indicating its potential as a treatment for ALI associated with smoking.
Article Abstract
This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294992 | PMC |
| http://dx.doi.org/10.3390/antiox12061258 | DOI Listing |
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