AI Article Synopsis
- Ezrin is an essential protein that helps organize the cytoskeleton, influencing cell shape, movement, and adhesion.
- It is crucial for tumor metastasis as it interacts with other proteins and immune cells, enabling cancer cells to evade immune responses.
- The text discusses Ezrin's functions, mechanisms, its involvement in metastasis, and its potential as a target for cancer treatment.
Article Abstract
Ezrin is the cytoskeletal organizer and functions in the modulation of membrane-cytoskeleton interaction, maintenance of cell shape and structure, and regulation of cell-cell adhesion and movement, as well as cell survival. Ezrin plays a critical role in regulating tumor metastasis through interaction with other binding proteins. Notably, Ezrin has been reported to interact with immune cells, allowing tumor cells to escape immune attack in metastasis. Here, we review the main functions of Ezrin, the mechanisms through which it acts, its role in tumor metastasis, and its potential as a therapeutic target.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10297006 | PMC |
| http://dx.doi.org/10.3390/cells12121620 | DOI Listing |
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