Bioinks are inks-in other words, hydrogels-prepared from biomaterials with certain physiochemical properties together with cells to establish hierarchically complex biological 3D scaffolds through various 3D bioprinting technologies [...].
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http://dx.doi.org/10.3390/bioengineering10060705 | DOI Listing |
Biomimetics (Basel)
December 2024
Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada.
Three-dimensional bioprinting (3DP) is transforming the field of regenerative medicine by enabling the precise fabrication of complex tissues, including the retina, a highly specialized and anatomically complex tissue. This review provides an overview of 3DP's principles, its multi-step process, and various bioprinting techniques, such as extrusion-, droplet-, and laser-based methods. Within the scope of biomimicry and biomimetics, emphasis is placed on how 3DP potentially enables the recreation of the retina's natural cellular environment, structural complexity, and biomechanical properties.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza St. 11/12, 80-233 Gdańsk, Poland.
Due to the numerous dangers arising from excessive use of antibiotics in treatments, researchers have been searching for natural alternatives to conventional antibiotics. Despite the popularity of plant extracts, essential oils, and their derivatives in herbal medicine, their applications in novel therapies are rather limited. This paper tries to open a new possibility for infection treatments by assessing the suitability of antimicrobial hydrogels as bioinks.
View Article and Find Full Text PDFSmall Methods
December 2024
Department for Functional Materials in Medicine and Dentistry, University Hospital of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.
A key goal of biofabrication is the production of 3D tissue models with biomimetic properties. In natural tissues, fibrils-mainly composed of collagen-play a critical role in stabilizing and spatially organizing the extracellular matrix. To use biomimetic fibers for reinforcing bioinks in 3D printing, fiber fragmentation is necessary to prevent nozzle clogging.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Division of Vascular Surgery, Department of General Surgery and Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Constructing scaffolds with the desired structures and functions is one of the main goals of tissue engineering. Three-dimensional (3D) bioprinting is a promising technology that enables the personalized fabrication of devices with regulated biological and mechanical characteristics similar to natural tissues/organs. To date, 3D bioprinting has been widely explored for biomedical applications like tissue engineering, drug delivery, drug screening, and in vitro disease model construction.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
Department of Biomedical Engineering & Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates.
Carbon-based polymeric nanocomposite hydrogels (NCHs) represent a groundbreaking advancement in biomedical materials by integrating nanoparticles such as graphene, carbon nanotubes (CNTs), carbon dots (CDs), and activated charcoal (AC) into polymeric matrices. These nanocomposites significantly enhance the mechanical strength, electrical conductivity, and bioactivity of hydrogels, making them highly effective for drug delivery, tissue engineering (TE), bioinks for 3D Bioprinting, and wound healing applications. Graphene improves the mechanical and electrical properties of hydrogels, facilitating advanced tissue scaffolding and drug delivery systems.
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