AI Article Synopsis
- Vitamin D supplementation may lower the incidence of diabetic nephropathy (DN), but causation was uncertain in this study.
- Researchers performed a Mendelian randomization analysis involving individuals with type I and type II diabetes-related nephropathy to investigate this relationship, while also examining other factors like KIM-1 and BMI.
- The results showed no causal association between vitamin D levels and diabetic nephropathy or kidney function in diabetic patients, suggesting that vitamin D may not have a direct impact on these conditions.
Article Abstract
Background: Vitamin D supplementation is associated with a lower incidence of diabetic nephropathy (DN); however, whether this association is causative is uncertain.
Methods: We used two-sample Mendelian randomization to examine the causal influence of vitamin D on diabetic nephropathy in 7,751 individuals with type I diabetes-related nephropathy (T1DN) and 9,933 individuals with type II diabetes-related nephropathy (T2DN). Meanwhile, we repeated some previous studies on the influence of KIM-1 (kidney injury molecule 1) and body mass index (BMI) on DN. Additionally, to test the validity of the instruments variable for vitamin D, we conducted two negative controls Mendelian randomization (MR) on breast and prostate cancer, and a positive control MR on multiple sclerosis.
Results: Results of the MR analysis showed that there was no causal association between 25(OH)D with the early/later stage of T1DN (early: OR = 0.903, 95%CI: 0.229 to 3.555; later: OR = 1.213, 95%CI: 0.367 to 4.010) and T2DN (early: OR = 0.588, 95%CI: 0.182 to 1.904; later: OR = 0.904, 95%CI: 0.376 to 2.173), nor with the kidney function of patients with diabetes mellitus: eGFRcyea (creatinine-based estimated GFR) (Beta = 0.007, 95%CI: -0.355 to 0.369)) or UACR (urinary albumin creatinine ratio) (Beta = 0.186, 95%CI: -0.961 to 1.333)).
Conclusions: We found no evidence that Vitamin D was causally associated with DN or kidney function in diabetic patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303333 | PMC |
| http://dx.doi.org/10.1186/s12882-023-03186-2 | DOI Listing |
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