AI Article Synopsis
- * A 68-year-old woman, initially treated with standard chemotherapy, showed disease progression but responded positively to the new combination therapy, leading to a significant reduction in metastatic lymph nodes.
- * The patient's successful conversion surgery, resulting in no detectable cancer in the lymph nodes, suggests that innovative therapies may improve outcomes for patients with this type of cancer.
Article Abstract
Background/aim: Mutant BRAF V600E colorectal cancer accounts for 5% of metastatic colorectal cancers, and it has a poor response to systemic chemotherapy and a poor prognosis. However, combination treatment involving MAPK pathway blockade is effective for this cancer. Herein, we report a case of a patient who underwent conversion surgery after encorafenib plus cetuximab for chemorefractory BRAF V600E-mutated colorectal cancer with para-aortic lymph node metastases.
Case Report: A 68-year-old woman was diagnosed with ascending colon cancer and multiple para-aortic lymph node metastases. After primary tumor resection, molecular genetic testing of the primary tumor revealed a BRAF V600E mutation. She was treated with FOLFOXIRI plus bevacizumab as first-line chemotherapy. After disease progression, the regimen was changed to encorafenib plus cetuximab, and the metastatic lesions shrank. She underwent para-aortic lymph node dissection as conversion surgery, and pathology revealed complete response of the lymph nodes. She achieved long-term survival.
Conclusion: The development of new treatments for BRAF V600E-mutated metastatic colorectal cancer will increase opportunities for conversion therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347918 | PMC |
| http://dx.doi.org/10.21873/invivo.13269 | DOI Listing |
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