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RB1 circulating-tumor DNA in the blood of Retinoblastoma patients increases in untreated patients.
Retina
August 2024
Department of Surgery, Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, United States.
Purpose: Circulating tumor DNA (ctDNA) in plasma has been identified in many cancers, including retinoblastoma at diagnosis. We have previously shown that with treatment (enucleation or ophthalmic artery chemosurgery (OAC)) all ctDNA disappears; and if there is persistent plasma ctDNA after treatment metastases develop. The purpose of this study was to determine how the ctDNA RB1 variant allele frequency (VAF) changes in patients with retinoblastoma who have delayed treatment.
View Article and Find Full Text PDFDisappearing retinoblastoma.
Can J Ophthalmol
August 2024
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa.. Electronic address:
Intravitreal Topotecan 90 µg for Recurrent Solid Retinoblastoma Tumors Is Effective and Not Toxic.
J Pediatr Ophthalmol Strabismus
March 2023
The authors report on the safety and efficacy of 90 µg/0.18 cc of intravitreal topotecan for recurrent solid retinal tumors in retinoblastoma. Topotecan 90 µg was injected intravitreally in three retinoblastoma cases that progressed after prior therapy.
View Article and Find Full Text PDFCell Free DNA (cfDNA) in the Blood of Retinoblastoma Patients The Robert M. Ellsworth Lecture.
Ophthalmic Genet
December 2022
Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background: Cell-free DNA analysis in cancer has gone from research to widespread clinical use in the past 10 years. At Memorial Sloan Kettering Cancer Center, we developed a technology and test to assay cell-free DNA (cfDNA) from blood (plasma) in our retinoblastoma patients.
Results: cfDNA derived from intraocular retinoblastoma can be measured and quantified in the blood (plasma) of patients.
Case Report: Phototherapeutic Keratectomy for Band Keratopathy Secondary to Chemo-Laser-Cryotherapy for Retinoblastoma.
Front Med (Lausanne)
August 2021
Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China.
To report the clinical outcomes of phototherapeutic keratectomy (PTK) for pediatric band keratopathy after treatment for retinoblastoma. A 5-year-old boy presented with a 2-year history of poor visual acuity and a horizontal gray-white band across the central cornea in the right eye. He was diagnosed with band keratopathy after chemo-laser-cryotherapy for retinoblastoma.
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