The eukaryotic translation initiation factor 4 (EIF4) family is a major contributor to the recruitment of mRNAs to ribosomes during the initial translation stage in eukaryotes, whose dysregulation either allows for cancer transformation or prevents disordered cancerous cell growth. Circular RNAs (circRNAs), which exhibit distinctive structures and are widely expressed in eukaryotes, are anticipated to be clinical diagnostic biomarkers for cancer therapy. There is considerable evidence that EIF4s can influence the biogenesis, transport, and function of circRNAs and, in turn, circRNAs can control the expressions of EIF4s through certain molecular pathways. Herein, we primarily review the emerging studies of the EIF4 family and pinpoint the roles of dysregulated EIF4s in cancer. We also evaluate the patterns of intricate interactions between circRNAs and EIF4s and discuss the potential utility of circRNA-based therapeutics targeting EIF4s in clinical cancer research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejphar.2023.175867 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
Sci Rep
August 2024
Department of Breast Surgery, Shanxi Provincial People's Hospital, Taiyuan, 030000, Shanxi, China.
Article Synopsis
- Translational control is key in regulating apoptosis, with the EIF4 protein family influencing how mRNA is translated, impacting breast cancer risk.
- The study used Mendelian randomization with genetic instrumental variables (EIF4E, EIF4B, EIF4A, EIF4EBP2) and focused on breast cancer cases from the BCAC consortium, analyzing both ER+ and ER- samples.
- Findings indicate that EIF4E increases breast cancer risk and shows a weak link to ER+ cancer but a stronger association with ER- cancer, while EIF4A does not affect ER+ cancer risk but raises the risk for ER- cancer; EIF4B and EIF4EBP2 showed no significant effects.
Eukaryotic translation initiation factor p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor.
Exp Ther Med
May 2024
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.
Essential tremor (ET) and Parkinson's disease (PD) are common chronic movement disorders that can cause a substantial degree of disability. However, the etiology underlying these two conditions remains poorly understood. In the present study, Whole-exome sequencing of peripheral blood samples from the proband and Sanger sequencing of the other 18 family members, and pedigree analysis of four generations of 29 individuals with both ET and PD in a nonconsanguineous Chinese family were performed.
View Article and Find Full Text PDFMolecular interplay between EIF4 family and circular RNAs in cancer: Mechanisms and therapeutics.
Eur J Pharmacol
September 2023
Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of Molecular Targeted Anti-tumor Drug Development and Evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address:
The eukaryotic translation initiation factor 4 (EIF4) family is a major contributor to the recruitment of mRNAs to ribosomes during the initial translation stage in eukaryotes, whose dysregulation either allows for cancer transformation or prevents disordered cancerous cell growth. Circular RNAs (circRNAs), which exhibit distinctive structures and are widely expressed in eukaryotes, are anticipated to be clinical diagnostic biomarkers for cancer therapy. There is considerable evidence that EIF4s can influence the biogenesis, transport, and function of circRNAs and, in turn, circRNAs can control the expressions of EIF4s through certain molecular pathways.
View Article and Find Full Text PDFThe roles of growth regulation and appendage patterning genes in the morphogenesis of treehopper pronota.
Proc Biol Sci
June 2022
Department of Biology, Duke University, Durham, NC 27708, USA.
Treehoppers of the insect family Membracidae have evolved enlarged and elaborate pronotal structures, which is hypothesized to involve co-opted expression of genes that are shared with the wings. Here, we investigate the similarity between the pronotum and wings in relation to growth. Our study reveals that the ontogenetic allometry of the pronotum is similar to that of wings in Membracidae, but not the outgroup.
View Article and Find Full Text PDFThe MATH-BTB Protein TaMAB2 Accumulates in Ubiquitin-Containing Foci and Interacts With the Translation Initiation Machinery in .
Front Plant Sci
November 2019
Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
MATH-BTB proteins are known to act as substrate-specific adaptors of CUL3-based E3 ligases in the ubiquitin proteasome pathway. Their BTB domain binds to CUL3 scaffold proteins and the less conserved MATH domain targets a highly diverse collection of substrate proteins to promote their ubiquitination and subsequent degradation. In plants, a significant expansion of the MATH-BTB family occurred in the grasses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!