AI Article Synopsis
- - The study focuses on identifying risk factors for ventilator-associated pneumonia (VAP) in children, particularly examining how therapeutic normothermia might contribute to its onset.
- - Out of 288 children treated with mechanical ventilation for over 48 hours, 2.4% developed VAP, with target temperature management at 36°C and methylprednisolone pulse therapy identified as significant risk factors.
- - The findings suggest that both therapeutic temperature management and corticosteroid treatment could increase the likelihood of developing VAP in pediatric patients.
Article Abstract
Background: In contrast to the adult population, limited information is currently available on risk factors for ventilator-associated pneumonia (VAP) in children. Therapeutic hypothermia has been identified as a risk factor for the early onset of VAP in adults; however, the relationship between VAP and normothermia remains unclear. The present study investigated risk factors for VAP in children, with a focus on the deleterious effects of therapeutic normothermia on VAP.
Methods: We retrospectively investigated the clinical characteristics of children treated with mechanical ventilation for more than 48 h and analyzed risk factors for VAP. The endpoint was the onset of VAP by the seventh day after the initiation of mechanical ventilation.
Results: Among the 288 patients enrolled, seven (2.4%) developed VAP. No significant differences were observed in clinical backgrounds between the VAP and non-VAP groups. A univariate analysis identified target temperature management (TTM) at 36°C (p < 0.0001) and methylprednisolone (mPSL) pulse therapy (p = 0.02) as risk factors for VAP. An analysis of the time to the onset of VAP by the Kaplan-Meier plot and log-rank test revealed a significantly higher incidence of VAP in the TTM group (p < 0.0001) and mPSL pulse group (p = 0.001).
Conclusion: TTM at 36°C and mPSL pulse therapy may be risk factors for VAP in the pediatric population.
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| http://dx.doi.org/10.1111/ped.15556 | DOI Listing |
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