Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Graphene oxide (GO) is a 2D nanomaterial with unique chemistry due to the combination of sp hybridization and oxygen functional groups (OFGs) even in single layer. OFGs play a fundamental role in the chemical functionalization of GO to produce GO-based materials for diverse applications. However, traditional strategies that employ epoxides, alcohols, and carboxylic acids suffer from low control and undesirable side reactions, including by-product formation and GO reduction. Thiol-ene "click" reaction offers a promising and versatile chemical approach for the alkene functionalization (-C=C-) of GO, providing orthogonality, stereoselectivity, regioselectivity, and high yields while reducing by-products. This review examines the chemical functionalization of GO via thiol-ene "click" reactions, providing insights into the underlying reaction mechanisms, including the role of radical or base catalysts in triggering the reaction. We discuss the "how" and "where" the reaction takes place on GO, the strategies to avoid unwanted side reactions, such as GO reduction and by-product formation. We anticipate that multi-functionalization of GO via the alkene groups will enhance GO physicochemical properties while preserving its intrinsic chemistry.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1002/chem.202301604 | DOI Listing |
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