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Body composition and body mass index measures from 8 to 18 years old in children with cystic fibrosis. | LitMetric

Body composition and body mass index measures from 8 to 18 years old in children with cystic fibrosis.

J Cyst Fibros

Discipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia; Department of Nutrition and Dietetics, Sydney Children's Hospital Randwick, New South Wales, Australia.

Published: September 2023

AI Article Synopsis

  • Historically, BMI >50th percentile was used to evaluate nutritional status in children with cystic fibrosis (CF), but fat-free mass index (FFMI) may provide a better measure of nutrition related to lung function.
  • The study analyzed body composition changes by age and gender in children with CF (8-18 years) through DXA scans, highlighting trends in FFMI and BMI.
  • Results showed weak positive correlations between FFMI and BMI with lung function, indicating that contemporary nutritional status may have less impact on lung function in CF than in the past.

Article Abstract

Background: Historically, body mass index (BMI) >50th percentile has represented optimal nutritional status in children with cystic fibrosis (CF) due to its positive association with lung function. Body composition parameters including fat-free mass index (FFMI) have been suggested as a more physiological nutrition benchmark.

Aims: (1) describe changes in body composition with age and gender; (2) assess the correlation between measures of nutritional status (FFMI-z, FMI-z, BMI-z) and lung function (forced expiratory volume in one second predicted; FEV1pp).

Methods: This retrospective, mixed cross-sectional and serial measures study consisted of children with CF (8 to 18 years) attending Sydney Children's Hospital (2007-2020). FFMI and fat mass index (FMI) were taken from biennial dual energy x-ray absorptiometry (DXA) scans. Z-scores were derived using Well's reference population [1]. Repeated measures correlation analyses assessed correlations between FFMI-z, FMI-z, and BMI-z with FEV1pp.

Results: 339 DXA reports were analysed from 137 patients. There were slight downwards trends in BMI-z and FMI-z, and an upwards trend in FFMI-z with increasing age and across both genders. Females had higher FMI-z and FFMI-z than males from 12.5 years. There was a weak, positive correlation between FEV1pp and BMI-z (r = 0.14, p = 0.04), and FFMI-z (r = 0.25, p<0.001). FMI-z had no correlation with FEV1pp (r=-0.06, p = 0.41).

Conclusion: Deficits in FFMI exist despite increasing trends with age. FFMI-z and BMI-z had a weak, positive correlation with FEV1pp. In contemporary cohorts, nutritional status (reflected by surrogate markers such as FFMI and BMI) may be less influential upon lung function than in previous decades. [1]: Wells, J.C., et al. Body-composition reference data for simple and reference techniques and a 4-component model: a new UK reference child. Am. J. Clin. Nutr.96, 1316-1326 (2012).

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Source
http://dx.doi.org/10.1016/j.jcf.2023.06.003DOI Listing

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