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New advances in novel pharmacotherapeutic candidates for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) between 2022 and 2024.
Acta Pharmacol Sin
January 2025
Department of Medical Microbiology & Parasitology, MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University Shanghai Medical College, Shanghai, 200032, China.
Metabolic dysfunction-associated steatotic liver disease (MASLD) covers a broad spectrum of profile from simple fatty liver, evolving to metabolic dysfunction-associated steatohepatitis (MASH), to hepatic fibrosis, further progressing to cirrhosis and hepatocellular carcinoma (HCC). MASLD has become a prevalent disease with 25% in average over the world. MASH is an active stage, and requires pharmacological intervention when there is necroptotic damage with fibrotic progression.
View Article and Find Full Text PDFGlobal, regional, national epidemiology and trends of Parkinson's disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021.
Front Aging Neurosci
January 2025
School of Nursing, Nanjing Medical University, Nanjing, China.
Aims: In light of the escalating global incidence of Parkinson's disease and the dearth of therapeutic interventions that can alter the disease's course, there exists an urgent necessity to comprehensively elucidate and quantify the disease's global burden.
Methods: This study analyzed the incidence, prevalence, and disability-adjusted life years (DALYs) of Parkinson's disease at global, regional, and national levels based on the Global Burden of Disease Study 2021. Bayesian age-period cohort (BAPC) analysis was used to predict the burden in Parkinson's disease from 2022 to 2035.
Mother-adolescent communication and father-adolescent communication: Analyzing a 4-week family intervention using multi-informant data.
J Res Adolesc
March 2025
Department of Psychology, University of Notre Dame, Notre Dame, Indiana, USA.
Families manage daily conflict through communication and healthy family communication is critical to promoting better family relationships and youth adjustment. Community families without high-risk factors, such as domestic dispute or clinical problems, are no less affected by the ramifications of poor communication and conflict management. However, there is limited translational research on community families analyzing the changes in parent-adolescent communication quality.
View Article and Find Full Text PDFTechnology usage and glycaemic outcomes in a single tertiary centre with an ethnically diverse and socioeconomically deprived cohort of children with type 1 diabetes mellitus.
Front Clin Diabetes Healthc
January 2025
Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
Background: The UK National Paediatric Diabetes Audit (NPDA) data reports disparities in Haemoglobin A1c (HbA1c) levels among children and young people (CYP) with Type 1 Diabetes (T1D), with higher levels in those of Black ethnic background and lower socioeconomic status who have less access to technology. We investigate HbA1c differences in a T1D cohort with higher than national average technology uptake where > 60% come from an ethnic minority and/or socioeconomically deprived population.
Design & Methods: Retrospective cross-sectional study investigating the influence of demographic factors, technology use, and socioeconomic status (SES) on glycaemic outcomes.
Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021.
Sci Rep
January 2025
Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Drum Tower Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
This study aimed to analyze the trends of early-onset colorectal cancer (EOCRC) among individuals aged 15 to 49 in China from 1990 to 2021 and compare them with global patterns using data from the Global Burden of Disease (GBD) study. The analysis focused on age-standardized incidence rates (ASIR), prevalence rates (ASPR), mortality rates (ASMR), and disability-adjusted life years (DALYs). Joinpoint regression was used to determine the average annual percentage change (AAPC), and the ARIMA model was employed to forecast trends from 2022 to 2050.
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