AI Article Synopsis
- Researchers developed biodegradable membranes for guided bone regeneration, incorporating beta-tricalcium phosphate (β-TCP) into a GelMA/PCL composite via electrospinning.
- These membranes exhibited a uniform porous structure, enhancing cell attachment and bone-related gene expression in stem cells from alveolar bone.
- In tests on rat bone defects, the GelMA/PCL-TCP membranes significantly outperformed other materials in promoting bone growth, confirming their potential for use in regenerative medicine.
Article Abstract
Major advances in the field of periodontal tissue engineering have favored the fabrication of biodegradable membranes with tunable physical and biological properties for guided bone regeneration (GBR). Herein, we engineered innovative nanoscale beta-tricalcium phosphate (β-TCP)-laden gelatin methacryloyl/polycaprolactone (GelMA/PCL-TCP) photocrosslinkable composite fibrous membranes via electrospinning. Chemo-morphological findings showed that the composite microfibers had a uniform porous network and β-TCP particles successfully integrated within the fibers. Compared with pure PCL and GelMA/PCL, GelMA/PCL-TCP membranes led to increased cell attachment, proliferation, mineralization, and osteogenic gene expression in alveolar bone-derived mesenchymal stem cells (aBMSCs). Moreover, our GelMA/PCL-TCP membrane was able to promote robust bone regeneration in rat calvarial critical-size defects, showing remarkable osteogenesis compared to PCL and GelMA/PCL groups. Altogether, the GelMA/PCL-TCP composite fibrous membrane promoted osteogenic differentiation of aBMSCs in vitro and pronounced bone formation in vivo. Our data confirmed that the electrospun GelMA/PCL-TCP composite has a strong potential as a promising membrane for guided bone regeneration.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982892 | PMC |
| http://dx.doi.org/10.1021/acsami.3c03059 | DOI Listing |
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