Objectives: Cryoglobulins (CGs) are serum proteins that undergo a reverse cold-induced precipitation . The CGs are a well-known cause of analytical interferences in several laboratory tests, leading to spurious results. With this in view, we present a case of a patient initially misdiagnosed due to CGs interference in Hepatitis C Virus (HCV) serology.
Case Presentation: We report a case of a woman of advanced age affected by acute renal failure that required urgent haemodialysis. In the absence of infections and other causes of CGs production, a diagnosis of acute renal failure secondary to essential cryoglobulinemia was established. However, an unexpected positive HCV viral load was encountered. At this point, a false-seronegative HCV infection conditioned to CGs interference was suspected, confirmed by repeating serology in pre-warmed serum. Finally, the patient was correctly diagnosed with HCV-secondary cryoglobulinemia.
Conclusions: As shown in the case, the presence of CGs in blood may represent a challenge for the correct interpretation of several laboratory tests. The identification of CGs and the pre-treatment of serum are decisive to avoid spurious results and reach a genuine diagnosis.
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http://dx.doi.org/10.1515/almed-2020-0086 | DOI Listing |
Adv Lab Med
May 2021
Clinical Chemistry Laboratory, Catalan Institute of Health (ICS)-Camp de Tarragona-Terres de l'Ebre, Joan XXIII University Hospital in Tarragona, Tarragona, Spain.
Objectives: Cryoglobulins (CGs) are serum proteins that undergo a reverse cold-induced precipitation . The CGs are a well-known cause of analytical interferences in several laboratory tests, leading to spurious results. With this in view, we present a case of a patient initially misdiagnosed due to CGs interference in Hepatitis C Virus (HCV) serology.
View Article and Find Full Text PDFMed Princ Pract
July 2006
Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Oman.
Objective: To detect hepatitis C virus (HCV) antibodies in seronegative donors by disruption of the immune complexes (ICs).
Subjects And Methods: HCV antibody detection was carried out on 600 seronegative donors following an IC dissociation assay. Reverse transcription polymerase chain reaction (RT-PCR) was then performed on the positive results.
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