AI Article Synopsis
- A 23-year-old pregnant woman developed pemphigus vulgaris, an autoimmune skin disorder, during her first trimester.
- In the 33rd week of pregnancy, she experienced a stillbirth of a female child who displayed significant skin lesions resembling pemphigus.
- Tests revealed IgG antibodies present in the skin of both the mother and child, suggesting that the mother's pemphigus antibodies may have crossed the placenta and caused the fetal skin condition.
Article Abstract
Pemphigus vulgaris developed in a 23-year-old woman during the first trimester of pregnancy. In the 33d week she had a stillbirth of a female child who showed extensive skin lesions clinically suggestive of pemphigus. The application of direct immunofluorescence staining to skin tissue sections showed deposition of IgG in the intercellular spaces of the epidermis of both mother and child. Our findings raise the possibility of transplacentar passage of pemphigus antibody, which may have been responsible for the fetal skin lesions.
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