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| http://dx.doi.org/10.1515/almed-2022-0052 | DOI Listing |
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Effect of an intensive lifestyle intervention on cystatin C-based kidney function in adults with overweight and obesity: From the PREDIMED-Plus trial.
J Intern Med
December 2024
Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain.
Background: Large-scale trials evaluating a multicomponent lifestyle intervention aimed at weight loss on kidney function are lacking.
Methods: This was a post hoc analysis of the "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) randomized controlled trial, including patients with overweight/obesity and metabolic syndrome, measured cystatin C and creatinine. Participants were randomly assigned (1:1) to an intensive weight loss lifestyle intervention (intervention group [IG]) consisting of an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support, or a control group (CG) receiving ad libitum MedDiet recommendations.
Plasma Biomarkers of Kidney Health and Mortality in Diabetes and Chronic Kidney Disease in the REGARDS Study.
Clin J Am Soc Nephrol
December 2024
Kidney Health Research Collaborative and Department of Medicine, University of California, San Francisco and San Francisco VA Health Care System, San Francisco, California.
Key Points: In diabetes and CKD, creatinine- and cystatin C–based eGFR has a strong inverse correlation with plasma TNF receptor 1, TNF receptor 2, and soluble urokinase-type plasminogen activator receptor. Higher plasma soluble TNF receptors 1 and 2 and soluble urokinase-type plasminogen activator receptor were each individually associated with mortality, independent of baseline kidney measures.
Background: Several plasma biomarkers of kidney health have been associated with CKD progression in persons with diabetes, but their associations with mortality risk have been largely unexplored.
Recommendations for European laboratories based on the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.
Clin Chem Lab Med
November 2024
Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU de Liège, Belgium.
The 2024 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for chronic kidney disease (CKD) evaluation and management bring important updates, particularly for European laboratories. These guidelines emphasize the need for harmonization in CKD testing, promoting the use of regional equations. In Europe, the European Kidney Function Consortium (EKFC) equation is particularly suited for European populations, particularly compared to the CKD-EPI 2021 race-free equation.
View Article and Find Full Text PDFDiscordance between creatinine and cystatin C-based estimation of glomerular filtration rate (eGFR) in solid organ transplant recipients.
Clin Biochem
November 2024
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. Electronic address:
Background: Estimation of glomerular filtration rate is a critical component of assessing kidney function post-solid organ transplantation and in monitoring risk of acute injury. Our objective was to evaluate estimated glomerular filtration rate (eGFR) as derived from creatinine (eGFR), cystatin C (eGFR), and both (eGFR) in a cohort of transplant recipients.
Methods: A total of 47 unique post-solid organ transplant patients receiving tacrolimus were included.
Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.
BMC Med Genomics
November 2024
College of Public Health, Southwest Medical University, Luzhou, Sichuan, China.
Article Synopsis
- - Chronic kidney disease (CKD) is a significant public health issue in China, particularly impacting women, and the study investigates genetic factors affecting renal function using a more accurate measurement method, eGFR based on both creatinine and cystatin C.
- - A Genome-Wide Association Study (GWAS) involving 1,983 Chinese women analyzed over 3.8 million genetic variants to explore their relationship with eGFRcr-cys, revealing one significant locus and two new suggestive loci linked to renal function.
- - The research identified three critical genetic variants associated with eGFRcr-cys, providing new insights into the biological mechanisms affecting kidney health and potential avenues for better diagnoses and treatments for CKD in the
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