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An Anticancer Bioactive Peptide Combined with Oxaliplatin Inhibited Gastric Cancer Cells and .
Curr Protein Pept Sci
January 2025
Key Laboratory of Medical Cell Biology in Inner Mongolia, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia,010050, China.
Background: Gastric cancer has become one of the major diseases threatening human health. This study aimed to investigate the mechanism of an anticancer bioactive peptide (ACBP) combined with oxaliplatin (OXA) on MKN-45, SGC7901, and NCI-N87 differentiated human gastric cancer cells and GES-1 immortalized human gastric mucosal epithelial cells. The therapeutic effect and action mechanism of short-term intermittent ACBP combined with OXA on nude mice with human gastric cancer were also investigated.
View Article and Find Full Text PDFSafety Study and Compositional Analysis of the Svarnvir-IV Tablet With Special Reference to Its Therapeutic Utility in SARS-CoV-2.
Cureus
December 2024
School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, IND.
Aim Traditional Ayurvedic herbo-mineral medicines have proven their potential in managing COVID-19. Cell-based assays of the Svarnvir-IV tablet demonstrated the virucidal activity against SARS-CoV-2 and its therapeutic action, along with safety in cytotoxicity, has been proved. In the present study, in vivo, safety profile and compositional analysis of the Svarnvir-IV tablet were performed.
View Article and Find Full Text PDFNo-Touch Saphenous Vein as Y-Composite vs Aortocoronary Graft: Early Outcome Analysis.
Ann Thorac Surg Short Rep
March 2024
Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: A randomized controlled trial was designed to compare 1-year morphologic changes of the no-touch saphenous vein (SV) as a Y-composite graft (composite group) vs an aortocoronary graft (aorta group) in coronary artery bypass grafting. This study evaluated early clinical and angiographic outcomes as a preliminary analysis.
Methods: The primary end point of the trial was the intima-media thickness measured by intravascular ultrasound at 1-year angiographic follow-up.
SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis.
Biomark Res
January 2025
Department of Hematology and Medical Oncology, Emory University, 201 Dowman Dr, Atlanta, GA, 30322, USA.
Background: Oncolytic viruses (OVs) are increasingly recognized as promising tools for cancer therapy, as they selectively infect and destroy tumor cells while leaving healthy cells unharmed. Despite considerable progress, the limited therapeutic efficacy of OV-based virotherapy continues to be a significant challenge in cancer treatment.
Methods: The SMAC/DIABLO gene was inserted into the genome of vesicular stomatitis virus (VSV) to generate VSV-S.
Morphological patterns of the European bison (Bison bonasus) skull.
Sci Rep
January 2025
Department of Morphological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, 02-776, Warsaw, Poland.
This study aimed to investigate the effects of environmental factors, sexual selection, and genetic variation on skull morphology by examining the skull structure of the European bison, a species at risk of extinction, and comparing it to other bovid species. The skull of the European bison was significantly bigger than that of other species of the tribe Bovini, and the results revealed considerable morphological differences in skull shape compared to other Bovini samples. The bison skull exhibited a broader shape in the frontal region and a more laterally oriented cornual process.
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