We analyze the role of disease containment policy in the form of treatment in a stochastic economic-epidemiological framework in which the probability of the occurrence of random shocks is state-dependent, namely it is related to the level of disease prevalence. Random shocks are associated with the diffusion of a new strain of the disease which affects both the number of infectives and the growth rate of infection, and the probability of such shocks realization may be either increasing or decreasing in the number of infectives. We determine the optimal policy and the steady state of such a stochastic framework, which is characterized by an invariant measure supported on strictly positive prevalence levels, suggesting that complete eradication is never a possible long run outcome where instead endemicity will prevail. Our results show that: (i) independently of the features of the state-dependent probabilities, treatment allows to shift leftward the support of the invariant measure; and (ii) the features of the state-dependent probabilities affect the shape and spread of the distribution of disease prevalence over its support, allowing for a steady state outcome characterized by a distribution alternatively highly concentrated over low prevalence levels or more spread out over a larger range of prevalence (possibly higher) levels.
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http://dx.doi.org/10.1007/s00199-023-01496-y | DOI Listing |
bioRxiv
November 2024
Princeton Neuroscience Institute, Princeton University.
Phys Rev E
October 2024
Department of Physics and Astronomy & Center for Theoretical Physics, Seoul National University, Seoul 08826, Republic of Korea.
Recent years have witnessed a surge of discoveries in the studies of thermodynamic inequalities: the thermodynamic uncertainty relation (TUR) and the entropic bound (EB) provide a lower bound on the entropy production (EP) in terms of nonequilibrium currents; the classical speed limit (CSL) expresses the lower bound on the EP using the geometry of probability distributions; the power-efficiency (PE) tradeoff dictates the maximum power achievable for a heat engine given the level of its thermal efficiency. In this study, we show that there exists a unified hierarchical structure encompassing all of these bounds, with the fundamental inequality given by an extension of the TUR (XTUR) that incorporates the most general range of currentlike and state-dependent observables. By selecting more specific observables, the TUR and the EB follow from the XTUR, and the CSL and the PE tradeoff follow from the EB.
View Article and Find Full Text PDFJ Phys Chem A
September 2024
State Key Laboratory of Molecular Reaction Dynamics and Dalian Coherent Light Source, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
The first high-resolution translational spectroscopy studies of D atom photoproducts following excitation to the Rydberg states of DS are reported. Excitation at wavelengths λ ∼ 139.1 nm reveals an unusual 'inverse' isotope effect; the B(3←2) Rydberg state of DS predissociates much faster than its counterpart in HS.
View Article and Find Full Text PDFPhys Rev Lett
August 2024
Department of Computational Mathematics, Science, and Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
We present a data-driven method to learn stochastic reduced models of complex systems that retain a state-dependent memory beyond the standard generalized Langevin equation with a homogeneous kernel. The constructed model naturally encodes the heterogeneous energy dissipation by jointly learning a set of state features and the non-Markovian coupling among the features. Numerical results demonstrate the limitation of the standard generalized Langevin equation and the essential role of the broadly overlooked state-dependency nature in predicting molecule kinetics related to conformation relaxation and transition.
View Article and Find Full Text PDFMed Image Anal
October 2024
National Center for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China. Electronic address:
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