To improve the efficiency of coal seam gas extraction, the influence characteristics of different factors on the penetration effect of cumulative blasting were determined and the hole spacing was effectively predicted; in this work, we used ANSYS/LS-DYNA numerical simulation software to establish the penetration model of cumulative blasting. Combined with an orthogonal design scheme, the crack radius prediction of cumulative blasting was studied. A prediction model for predicting the fracture radius of cumulative blasting based on three groups of different factors was established. The results showed that the primary and secondary order of factors that affected the fracture radius of cumulative blasting was as follows: ground stress > gas pressure > coal firmness coefficient. The penetration effect decreased with increasing ground stress and decreased with an increase in the gas pressure and coal firmness coefficient. The industrial field test was carried out. The gas extraction concentration increased by 73.4% after cumulative blasting, and the effective crack radius of cumulative blasting was approximately 5.5-6 m. The maximum error of the numerical simulation was 1.2%, and the maximum error of the industrial field test was 6.22%, which proved that the crack radius prediction model of cumulative blasting was correct.
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http://dx.doi.org/10.1021/acsomega.3c02453 | DOI Listing |
Int J Mol Sci
December 2024
McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Military breachers are routinely exposed to repetitive low-level blast overpressure, placing them at elevated risk for long-term neurological sequelae. Mounting evidence suggests that circulating brain-reactive autoantibodies, generated following CNS injury, may serve as both biomarkers of cumulative damage and drivers of secondary neuroinflammation. In this study, we compared circulating autoantibody profiles in military breachers ( = 18) with extensive blast exposure against unexposed military controls ( = 19).
View Article and Find Full Text PDFExp Hematol Oncol
January 2025
Bone Marrow Transplantation Center of The First Affiliated Hospital Liangzhu Laboratory, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang, China.
Background: Sequential CD19 and CD22 chimeric antigen receptor (CAR)-T cell therapy offers a promising approach to antigen-loss relapse in relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL); however, research in adults remains limited.
Methods: This study aimed to evaluate the efficacy and safety of sequential CD19 and CD22 CAR-T cell therapy in adult patients with R/R B-ALL between November 2020 and November 2023 (ChiCTR2100053871). Key endpoints included the adverse event incidence, overall survival (OS), and leukemia-free survival (LFS).
Neurotrauma Rep
December 2024
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Cancers (Basel)
November 2024
Department of Hematology, Hemotherapy and Cell Therapy, Faculty of Medicine, University of Sao Paulo (FM-USP), Sao Paulo 05508-090, Brazil.
Clinical staging (CS) and tumor burden (TB) play a significant role in FL prognosis and direct its up-front therapy. The aim of this study is to report prognostic factors and clinical outcomes in newly-diagnosed FL patients stratified according to CS and TB in early-stage (ES) disease, advanced-stage with low tumor burden (AS-LTB) and advanced-stage with high tumor burden (AS-HTB). Two hundred fourteen patients with FL grades 1-3A had baseline clinical characteristics and outcomes assessed.
View Article and Find Full Text PDFBone Marrow Transplant
November 2024
Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.
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