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Periodontal inflammation is associated with increased circulating levels of endothelial progenitor cells: a retrospective cohort study in a high vascular risk population. | LitMetric

AI Article Synopsis

Article Abstract

Background: One of the main biological mechanisms behind the link between periodontitis and atherosclerotic vascular diseases is vascular endothelial dysfunction. Particularly, circulating endothelial progenitor cells (EPCs) have been considered a biomarker of altered vascular endothelial function.

Objectives: The aim of this study was to investigate relationship between periodontal inflammation and increased number of circulating EPCs.

Design: This is retrospective cohort study.

Methods: In this study, 85 elderly patients with a previous history of hypertension were followed up to 12 months. A baseline full-mouth periodontal assessment was carried out, and the amount of periodontal tissue inflamed per subject was calculated as a proxy of periodontal inflammation [periodontal inflamed surface area (PISA)]. The number of circulating EPCs (CD34/CD133/KDR) was determined by flow cytometry from peripheral blood samples collected at baseline and 12 months.

Results: Mean concentrations of CD34/CD133/KDR progenitor cells were higher in periodontitis patients than in those without periodontitis at baseline [55.4, 95% confidence interval (CI) = 20.8 to 90.0 27.2, 95% CI = 13.6 to 40.8,  = 0.008] and 12 months (114.6, 95% CI = 53.5 to 175.7 19.1, 95% CI = 10.8 to 27.4,  = 0.003). A significant increase over the follow-up was noticed in the group of subjects with periodontitis ( = 0.049) but not in the nonperiodontitis group ( = 0.819). PISA was independently associated with CD34/CD133/KDR EPCs at baseline ( coefficient = 0.031, 95% CI = 0.005 to 0.058;  = 0.021). The relationship between PISA and CD34/CD133/KDR EPCs at 12 months was confounded by increased baseline body mass index ( coefficient = 0.064, 95% CI = -0.005 to 0.132;  = 0.066).

Conclusion: Periodontal inflammation is associated with high number of CD34/CD133/KDR EPCs, thus supporting a potential link between periodontitis and endothelial dysfunction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285583PMC
http://dx.doi.org/10.1177/20406223231178276DOI Listing

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