AI Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) is a major cause of long-term neurological issues in both newborns and adults, prompting a review of current research through bibliometric analysis.
- The study highlights various animal models and methods for HIE research, as well as differing opinions on neuroprotective treatments, particularly focusing on therapeutic hypothermia.
- The authors discuss advancements in understanding neural circuits and injured brain tissue, aiming to combine neuroendocrine approaches with neuroprotection for improved HIE treatment and prognosis.
Article Abstract
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of long-term neurological disability in neonates and adults. Through bibliometric analysis, we analyzed the current research on HIE in various countries, institutions, and authors. At the same time, we extensively summarized the animal HIE models and modeling methods. There are various opinions on the neuroprotective treatment of HIE, and the main therapy in clinical is therapeutic hypothermia, although its efficacy remains to be investigated. Therefore, in this study, we discussed the progress of neural circuits, injured brain tissue, and neural circuits-related technologies, providing new ideas for the treatment and prognosis management of HIE with the combination of neuroendocrine and neuroprotection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288156 | PMC |
| http://dx.doi.org/10.3389/fnins.2023.1136500 | DOI Listing |
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