AI Article Synopsis
- Two new cinnamoyl-containing nonribosomal peptides, grisgenomycin A and B, were discovered in specific strains of bacteria through genome mining.
- These peptides are unique bicyclic decapeptides with a novel carbon-carbon bond linking tryptophan to a cinnamoyl group.
- Grisgenomycins showed potential antiviral activity against human coronaviruses at low concentrations (micromolar level).
Article Abstract
Two novel cinnamoyl-containing nonribosomal peptides (CCNPs) grisgenomycin A and B were identified in NBRC 13350 (CGMCC 4.5718) and ATCC 12475, through genome mining using conserved adjacent LuxR family regulators as probes and activators. Notably, grisgenomycins represent a new group of bicyclic decapeptides featuring an unprecedented C-C bond between the tryptophan carbocycle and the cinnamoyl group. A plausible biosynthetic pathway for grisgenomycins was deduced by a bioinformatics analysis. Grisgenomycins exhibited activity against human coronaviruses at the micromolar level.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.3c01683 | DOI Listing |
Publication Analysis
Top Keywords
cinnamoyl-containing nonribosomal
8
nonribosomal peptides
8
genome-directed discovery
4
discovery bicyclic
4
bicyclic cinnamoyl-containing
4
peptides anticoronaviral
4
anticoronaviral activity
4
activity novel
4
novel cinnamoyl-containing
4
peptides ccnps
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!