A novel Ru-catalyzed redox-neutral [4+2] cyclization of 2-arylbenzimidazoles with α-trifluoromethyl-α-diazoketones has been achieved through sequential C-H activation and defluorinative annulation. This synthetic protocol unlocks modular and expeditious access to 6-fluorobenzimidazo[2,1-]isoquinolines with high efficiency and excellent functional group compatibility. The resultant monofluorinated heterocyclic products can readily diversified by various nucleophiles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.3c01296 | DOI Listing |
Publication Analysis
Top Keywords
c-h activation
8
activation defluorinative
8
defluorinative annulation
8
2-arylbenzimidazoles α-trifluoromethyl-α-diazoketones
8
cascade c-h
4
annulation 2-arylbenzimidazoles
4
α-trifluoromethyl-α-diazoketones modular
4
modular assembly
4
assembly 6-fluorobenzimidazo[21-]isoquinolines
4
6-fluorobenzimidazo[21-]isoquinolines novel
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!