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Safety and Efficacy of IV Onasemnogene Abeparvovec for Pediatric Patients With Spinal Muscular Atrophy: The Phase 3b SMART Study.
Neurology
January 2025
The Dubowitz Neuromuscular Centre, Developmental Neurosciences Department, University College London, Great Ormond Street Institute of Child Health, United Kingdom.
Background And Objectives: Safety and efficacy of IV onasemnogene abeparvovec has been demonstrated for patients with spinal muscular atrophy (SMA) weighing <8.5 kg. SMART was the first clinical trial to evaluate onasemnogene abeparvovec for participants weighing 8.
View Article and Find Full Text PDFA Review of the Prospera Spinal Cord Stimulation System with Multiphase Stimulation and Proactive Care.
Curr Pain Headache Rep
January 2025
Department of Anesthesiology, Rush University Medical Center, Chicago, IL, USA.
Purpose Of Review: The purpose of this review is to describe the development and key features of the Prospera™ Spinal Cord Stimulation (SCS) System, as well as the clinical evidence supporting its use. Prospera delivers therapy using a proprietary multiphase stimulation paradigm and is the first SCS system to offer proactive care through automatic, objective, daily, remote device monitoring and remote programming capabilities.
Recent Findings: Results from the recently published BENEFIT-02 trial support the short-term safety and efficacy of multiphase stimulation in patients with chronic pain.
Does communicating measurable diversity goals attract or repel historically marginalized job applicants? Evidence from the lab and field.
J Exp Psychol Gen
January 2025
Department of Negotiation, Organizations and Markets, Harvard Business School, Harvard University.
Many organizations struggle to attract a demographically diverse workforce. How does adding a measurable goal to a public diversity commitment-for example, "We care about diversity" versus "We care about diversity and plan to hire at least one woman or racial minority for every White man we hire"-impact application rates from women and racial minorities? Extant psychological theory offers competing predictions about how historically marginalized applicants might respond to such goals. On one hand, measurable diversity goals may raise belongingness concerns among marginalized group members who are uncomfortable with being recruited and hired based on their demographics.
View Article and Find Full Text PDFEfficacy of platelet-rich plasma injection for pain relief in injured athletes: a systematic review of randomized controlled trials.
J Sports Med Phys Fitness
January 2025
Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
Introduction: Sports injuries involving bi-articular muscles like the hip flexors, hamstrings, quadriceps, and gastrocnemius significantly affect athletes' performance and quality of life. Comprehensive rehabilitation is crucial for a pain-free return to play (RTP). Over the past 15 years, platelet-rich plasma (PRP) has emerged for its potential in tissue regeneration.
View Article and Find Full Text PDFCognitive stimulation to improve cognitive functioning in people with dementia.
Cochrane Database Syst Rev
January 2023
Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
Background: Cognitive stimulation (CS) is an intervention for people with dementia offering a range of enjoyable activities providing general stimulation for thinking, concentration and memory, usually in a social setting, such as a small group. CS is distinguished from other approaches such as cognitive training and cognitive rehabilitation by its broad focus and social elements, aiming to improve domains such as quality of life (QoL) and mood as well as cognitive function. Recommended in various guidelines and widely implemented internationally, questions remain regarding different modes of delivery and the clinical significance of any benefits.
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