Cytomorphology along with positive AE1/AE3 staining and Brachyury staining support the dignosis of metastatic dedifferentiated chordoma.
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http://dx.doi.org/10.1111/cyt.13261 | DOI Listing |
N Am Spine Soc J
March 2025
Department of Orthopaedics, Rutgers New Jersey Medical School, Newark, New Jersey, United States.
Background: Chordoma is a rare bone cancer arising from the embryonic notochord with special predilection to the axial skeleton. The locally destructive nature and metastatic potential of chordomas can lead to devastating outcomes in terms of survival. The purpose of this study was to examine potential risk factors predictive of metastatic disease at presentation and prognostic factors in patients with metastasis.
View Article and Find Full Text PDFJ Neurooncol
November 2024
East Carolina University Brody School of Medicine, 600 Moye Blvd, Greenville, NC, 27834, USA.
Cancer Immunol Immunother
September 2024
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy.
Background: The antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. Proper functioning of APM components is essential for presenting these antigens on the surface of tumor cells, enabling immune detection and destruction. In many cancers, defects in APM can lead to immune evasion, contributing to tumor progression and poor clinical outcomes.
View Article and Find Full Text PDFEur Spine J
September 2024
Pathology Department, La Paz University Hospital, Paseo de la Castellana, 261, Madrid, 28046, Spain.
Int J Mol Sci
May 2024
Department of Neurological Surgery, University of Oklahoma, Oklahoma City, OK 73104, USA.
Chordomas, arising from notochord remnants, are rare neoplasms with aggressive growth patterns despite their histologically low-grade nature. This review explores their embryological origins, molecular markers like brachyury, and genetic alterations driving pathogenesis. Diagnosis relies on advanced imaging and biopsy confirmation due to overlapping features with chondrosarcoma.
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