AI Article Synopsis
- A new method for creating enantioenriched 1,4-benzoxazepines has been developed using a sequential asymmetric conjugate addition and cyclisation of α-bromohydroxamates with quinone methide derivatives.
- The process yields high product quantities (up to 95%) and good enantioselectivities (up to a ratio of 97:3).
- This technique highlights the effectiveness of α-bromohydroxamates as versatile building blocks in creating complex chiral compounds through asymmetric cyclisation.
Article Abstract
A sequential asymmetric conjugate addition/cyclisation of α-bromohydroxamates with -quinone methide derivatives has been developed, which provides enantioenriched 1,4-benzoxazepines in generally high yields (up to 95%) and good enantioselectivities (up to 97 : 3 er). This protocol not only offers a novel and straightforward strategy for constructing chiral 1,4-benzoxazepines, but also demonstrates the potential of α-bromohydroxamates as three-atom synthons in asymmetric cyclisation reactions.
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| http://dx.doi.org/10.1039/d3cc02368k | DOI Listing |
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