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PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility.
Sci China Life Sci
July 2023
Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Institute of Reproduction and Development, Fudan University, Shanghai, 200011, China.
The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility.
Sci China Life Sci
July 2023
Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.
PIWI-clade proteins harness piRNAs of 24-33 nt in length. Of great puzzles are how PIWI-clade proteins incorporate piRNAs of different sizes and whether the size matters to PIWI/piRNA function. Here we report that a PIWI-Ins module unique in PIWI-clade proteins helps define the length of piRNAs.
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