Aspergillus spondylodiscitis is a rare entity reported in the literature. In tuberculosis endemic regions like India, more often it could be misdiagnosed as tuberculous spondylodiscitis. Herein we report a case series of three patients with Aspergillus spondylodiscitis presenting with chronic low backpain and clinically diagnosed as tuberculosis spine. Culture and histopathological examination of the debrided tissue provided a definite diagnosis. Interestingly, one of the cases had coexisting tuberculosis spine. All three patients underwent surgical intervention-debridement, decompression and fusion of spine and combined medical management with voriconazole with successful outcome.

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http://dx.doi.org/10.1016/j.ijmmb.2023.02.006DOI Listing

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  • A case of spondylodiscitis caused by Aspergillus fumigatus was successfully treated with isavuconazole after the patient showed severe intolerance to the standard treatment, voriconazole.
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  • While current research on isavuconazole specifically for spondylodiscitis is limited, this case adds to the evidence supporting its use in treating this serious condition.
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