Objectives: To investigate the effect of daily use of a lozenge containing arginine and probiotics for 10-12 months on caries increment, gingivitis- and plaque occurrence in children aged 5-9 years.
Methods: In this placebo-controlled, double-blinded, parallel-grouped randomized clinical trial, 343 children were randomly assigned to one of the study arms (1:1). The intervention group (n = 172) received a lozenge containing Lacticaseibacillus rhamnosus, LGG® (DSM33156), Lactobacillus paracasei subsp. paracasei, L. CASEI 431® (DSM33451) and prebiotic (arginine 2%). The placebo group (n = 171) received an identical lozenge without arginine or probiotics. Primary canines and molars, and permanent first molars were examined clinically (d/D= ICDAS) and radiographically (d/D = R) at baseline and follow-up. Missing (m/M), sealed (s/S), and filled (f/F) surfaces (-s/-S) in both dentitions were also included. Utilizing clinical and radiographic scorings, caries experience was classified as dmsf-s (primary teeth), DMSF-S (permanent teeth), d/D m/M-s/S-f/F-s/S (mixed dentition). A weighted and an unweighted score system was applied.
Results: The study was completed by 288 children. The dropout rate was 15%. The increase in ∆mean dmsf-s and ∆mean d/Dm/M-s/S-f/F-s/S was lower in the intervention group (p = 0.007). No differences were found for gingivitis- and plaque occurrence. No product-related side effects were reported. This study followed ICH-GCP including external monitoring.
Conclusion: Daily consumption of a lozenge containing prebiotic arginine and two strains of probiotics showed safe use and statistically significantly reduction in caries incrementbut no effect on the mean plaque or gingivitis occurrence in children. The use of a lozenge with arginine and probiotics combined has a promising potential as a supplementary tool for future management of caries. www.
Clinicaltrials: gov (NCT03928587).
Clinical Significance: The combination of prebiotic arginine and probiotics shows clinical potential as a supplementary approach to toothbrushing with fluoride toothpaste in managing caries increment in children. A new era in the management of caries may be emerging.
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http://dx.doi.org/10.1016/j.jdent.2023.104599 | DOI Listing |
J Biol Chem
December 2024
School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China. Electronic address:
Base editing is preferable for bacterial gene inactivation without generating double strand breaks, requiring homology recombination or highly efficient DNA delivery capability. However, the potential of base editing is limited by the adjoined dependence on the editing window and protospacer adjacent motif (PAM). Herein, we report an unconstrained base editing system to enable the inactivation of any genes of interest (GOIs) in bacteria.
View Article and Find Full Text PDFJ Food Sci
December 2024
Department of Food Science and Technology, National University of Singapore, Singapore, Singapore.
Given the growing interest in dairy-free milk analog products, new and diversified alternatives are pivotal to push the market forward. Germination and fermentation are traditional processing technologies used in plant-based milk production. However, the combination of both has not been extensively investigated.
View Article and Find Full Text PDFJ Proteomics
December 2024
College of Animal Science, Guizhou University, Guiyang 550025, China; Institute of Animal Diseases, Guizhou University, Guiyang 550025, China. Electronic address:
Inflammatory bowel disease is characterized by severe imbalance of intestinal flora and metabolic disorders. Recent studies have demonstrated that probiotics can effectively alleviate inflammatory bowel disease by restoring the intestinal flora structure and modulating the immune response. However, the role of probiotics in regulating intestinal metabolism disorders is still unclear.
View Article and Find Full Text PDFFood Sci Nutr
November 2024
Dental Research Center, Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran.
BMJ
November 2024
Department of Anesthesia, McMaster University, Hamilton, ON, Canada.
Objective: To compare the effectiveness of interventions for the management of long covid (post-covid condition).
Design: Living systematic review.
Data Sources: Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials from inception to December 2023.
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