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Morvan's Syndrome with Myasthenia Gravis: An Autoimmune or Paraneoplastic Association?
Ann Indian Acad Neurol
September 2024
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
A case series: Three cases of Morvan's syndrome as a rare autoimmune disorder with anti-Caspr2 antibody.
Medicine (Baltimore)
October 2024
Clinical Department of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, China.
Article Synopsis
- Morvan syndrome is a rare autoimmune disorder primarily affecting males, characterized by symptoms like muscle twitching, autonomic disturbances, and severe sleep issues, often linked to specific autoantibodies.
- Current treatments include various immunotherapies, but no long-term cure exists, prompting interest in alternative therapies like traditional Chinese medicine.
- Three patients with serum Caspr2-positive Morvan syndrome showed some relief from traditional treatments but experienced disease recurrence, indicating the complexity and unpredictability of the condition.
A Case Report of an Atypical Presentation of Morvan Syndrome.
Cureus
September 2024
Internal Medicine, California Hospital Medical Center, Los Angeles, USA.
Article Synopsis
- Morvan syndrome, or Morvan's fibrillary chorea, is a rare neurological condition linked to cancer, showing symptoms that affect the CNS, peripheral nerves, and autonomic functions.
- A case study highlighted an adult female who suddenly experienced chest pain, weakness, and muscle spasms, revealing positive VGKC and amphiphysin antibodies in her blood.
- The diagnosis of Morvan syndrome involves recognizing myokymia, positive VGKC antibodies, and neuropsychiatric symptoms, with this case demonstrating a unique link to amphiphysin positivity.
A rare case of LGI1 antibody-positive Morvan syndrome with myasthenia gravis.
Med Clin (Barc)
December 2024
Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
The neurobiology and immunology of CASPR2-associated neurological disorders.
Rev Neurol (Paris)
November 2024
Service de neurologie clinique et fonctionnelle, groupe hospitalier Sud, hospices civils de Lyon, Lyon, France; Centre de référence pour les encéphalites auto-immunes et les syndromes neurologiques paranéoplasiques, hospices civils de Lyon, Lyon, France. Electronic address:
CASPR2-associated neurological disorders encompass a wide clinical spectrum broadly divided into overlapping three autoimmune syndromes: CASPR2 limbic encephalitis, Morvan syndrome, and Isaacs syndrome. CASPR2 is a neuronal protein expressed at different sites in the central and peripheral nervous system and has a variety of roles and functions regarding neuronal excitability, synaptic plasticity, and homeostasis of inhibitory networks, most of which are only partially understood. CASPR2 antibodies have various pathogenic effects including internalization of CASPR2, disruption of protein-protein interactions, and, possibly, complement activation.
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