AI Article Synopsis
- * Historically, ATF3 has been seen as harmful in certain heart conditions, but recent research highlights its potential protective roles against oxidative stress and metabolic imbalances.
- * This review aims to delve into ATF3's protective mechanisms in heart dysfunction, suggesting it could be a valuable target for preventing and treating cardiovascular diseases.
Article Abstract
Activation transcription factor 3 (ATF3), a member of the ATF/cyclic adenosine monophosphate response element binding family, can be induced by a variety of stresses. Numerous studies have indicated that ATF3 plays multiple roles in the development and progression of cardiovascular diseases, including atherosclerosis, hypertrophy, fibrosis, myocardial ischemia-reperfusion, cardiomyopathy, and other cardiac dysfunctions. In past decades, ATF3 has been demonstrated to be detrimental to some cardiac diseases. Current studies have indicated that ATF3 can function as a cardioprotective molecule in antioxidative stress, lipid metabolic metabolism, energy metabolic regulation, and cell death modulation. To unveil the potential therapeutic role of ATF3 in cardiovascular diseases, we organized this review to explore the protective effects and mechanisms of ATF3 on cardiac dysfunction, which might provide rational evidence for the prevention and cure of cardiovascular diseases.
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| http://dx.doi.org/10.1016/j.lfs.2023.121869 | DOI Listing |
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