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Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from K18-0086.
ACS Omega
April 2024
O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Article Synopsis
- - A new physicochemical screening method using d-Ala-d-Ala silica gel led to the discovery of two macrolactams, banglactams A and B, from the K18-0086 culture broth.
- - The d-Ala-d-Ala silica gel effectively differentiated and separated the banglactams, but the instability and insolubility of one prevented structural elucidation initially.
- - By chemically modifying the unstable compound, researchers improved its solubility, allowing for further study, and found that banglactams exhibited antibacterial activity when bound to the silica gel.
A Case of Convergent Evolution: The Bacterial Sesquiterpene Synthase for 1-epi-Cubenol from Nonomuraea coxensis.
Chembiochem
December 2023
Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.
A terpene synthase from Nonomuraea coxensis was identified as (+)-1-epi-cubenol synthase. The enzyme is phylogenetically unrelated to the known enzyme of the same function that is widespread in streptomycetes. Isotopic labelling experiments were performed to unambiguously assign the NMR data and to investigate hydrogen migrations during terpene cyclisations.
View Article and Find Full Text PDFA case of Nonomuraea blood infection, Beijing, China.
Clin Microbiol Infect
October 2023
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Nosocomial Infection, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address:
Emerging Fungal Infections in the Era of Antibiotic Stewardship.
Case Rep Infect Dis
June 2019
Kingman Regional Medical Center, Department of Emergency Medicine, 3269 Stockton Hill Road, Kingman, AZ 86409, USA.
Pneumonia is one of the most common causes of infection seen worldwide and still remains one of the most common causes of mortality despite significant advancements in medicine. With the increase in immunosuppression and antimicrobial usage, emerging infectious agents have been isolated in patients with pneumonia. The authors present a case in which , , and were isolated from a bronchoalveolar lavage from an immunosuppressed patient with pneumonia.
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