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Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection.
Mucosal Immunol
January 2025
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh Medical Center Pittsburgh PA USA; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine New Haven CT USA. Electronic address:
Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.
View Article and Find Full Text PDFAwaiting insurance coverage: Medicaid enrollment and post-acute care use after traumatic injury.
J Trauma Acute Care Surg
January 2025
From the Section of Trauma and Acute Care Surgery, Department of Surgery (D.N.H., J.S.H.), University of Chicago, Chicago, Illinois; Perelman School of Medicine (E.C.E., A.T.C., O.I.R., A.U.M., M.K.D., N.D.M., M.J.S., E.J.K.), Division of Trauma, Surgical Critical Care and Emergency Surgery (K.M.C., N.D.M., M.J.S., E.J.K.), University of Pennsylvania, Philadelphia, Pennsylvania; and Department of Surgery (L.M.K.), Stanford University, Stanford, California.
Background: Lack of insurance after traumatic injury is associated with decreased use of postacute care and poor outcomes. Insurance linkage programs enroll eligible patients in Medicaid at the time of an unplanned admission. We hypothesized that Medicaid enrollment would be associated with increased use of postacute care, but also with prolonged hospital length of stay (LOS) while awaiting insurance authorization.
View Article and Find Full Text PDFOptimizing Clinical Postgraduate Training: Perspectives of Postgraduate Alumni Regarding Their Residency Training at Mbarara University of Science and Technology, Uganda.
Adv Med Educ Pract
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Background: Understanding alumni satisfaction and the competencies gained during university training can guide improvements in education quality, particularly in higher education institutions. This study at Mbarara University of Science and Technology (MUST) explored the factors influencing alumni decisions, their residency experiences, and their levels of satisfaction. Additionally, it provided recommendations for improving graduate training programs.
View Article and Find Full Text PDFInitial Management of Acute Pancreatitis.
Gastroenterol Clin North Am
March 2025
Gastroenterology Department, Dr. Balmis General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL), Servicio de Aparato Digestivo, 4 planta C, Pintor Baeza 12, 03010, Alicante, Spain; Clinical Medicine Department, Miguel Hernandez University, Campus UMH de Sant Joan, Edificio Francisco Javier Balmis, Carretera Nacional 332 s/n, 03550, San Juan de Alicante, Spain. Electronic address:
The initial management of acute pancreatitis (AP) is continually evolving. Goal-directed moderate fluid resuscitation is now preferred over more aggressive strategies. Antibiotics should be administered only when there is a proven or highly probable infection rather than for prophylactic purposes.
View Article and Find Full Text PDFFactors associated with ICU stays after endovascular treatments for unruptured intracranial aneurysms: A review study.
J Clin Neurosci
January 2025
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Background: For unruptured intracranial aneurysms (UIAs), conservative management is often possible. However, when direct treatment is warranted, endovascular treatments (EVTs) provide an effective minimally invasive approach. These procedures still necessitate careful patient monitoring, frequently in the Intensive Care Unit (ICU).
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